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Dong Ryul Lee

Dong Ryul Lee

전공Developmental biology and physiology
연락처 031-881-7136 drleedr@cha.ac.kr

학력

  • 한양대학교 자연과학대학 생물학과 ( 이학사 )
  • 한양대학교 대학원 생물학과 ( 이학석사 )
  • 한양대학교 대학원 생물학과 ( 이학박사 )

경력

  • 1993-1999: 영동제일병원 수석연구원
  • 1999-2002: 미국 Cornell University Postdoctoral associate
  • 2001 – 현재: 차 의과학대학교 의생명과학과 교수
  • 2001 – 2016: 차병원 여성의학연구소 연구부장
  • 2008 – 2012: 21세기 프론티어사업 세포응용사업단 3기 기획위원
  • 2008 – 2014: 차 의과학대학교 줄기세포 연구소 부소장
  • 2014 – 현재: 차 의과학대학교 실험동물센터 센터장
  • 2015 – 현재: 차 의과학대학교 줄기세포 연구소 소장
  • 2016 – 현재: 대한남성과학회 부회장
  • 2017 – 2018: 차 의과학대학교 일반대학원장

논문

    [연구분야]
  • 줄기세포 및 역분화 기전 연구
  • 생식세포
  • 세포치료제 개발

    • [연구내용]

    본 연구실은 포유류의 생식세포인 난자와 정자의 생성, 분화, 그리고 동결보존을 연구를 하고 있습니다. 또한 난자와 정자의 수정과정과, 이로 인해 형성된 배아의 초기발생과정과, 배아줄기세포 및 정원줄기세포의 확립 및 분화에 관한 연구를 진행하고 있습니다. 최근 체세포복제줄기세포 (SCNT-ES)를 포함한 줄기세포로의 역분화와 분화조절기전을 연구하고 있습니다. 또한 불임시술관련 임상과 연계되어 생식의학과 생식생리학 분야의 연구를 수행합니다.



    [논문]
  • Sung‐Min Jun1, Mira Park2, Ji Yoon Lee ,Sookyung Jung , Jeoung Eun Lee ,Sung Han Shim, Haengseok Song, Dong Ryul Lee, Single cell‐derived clonally expanded mesenchymal progenitor cells from somatic cell nuclear transfer‐derived pluripotent stem cells ameliorate the endometrial function in the uterus of a murine model with Asherman’s syndrome, Cell profileration.2019
  • Ah Reum Lee, Kwonho Hong, Seo Hye Choi, Chanhyeok Park, Jae Kyun Park, Jin Il Lee, Jae Il Bang,Dong-Won Seol, Jeoung Eun Lee, and Dong Ryul Lee1,Anti-apoptotic Regulation Contributes to the Successful Nuclear Reprogramming Using Cryopreserved Oocytes, Stem Cell Reports,2019
  • SOON-JUNG PARK, JI-HEON LEE, SEUL-GI LEE, JEOUNG EUN LEE,JOSEPH SEO,JONG JIN CHOI,TAEK-HEE JUNG,EUN-BIN CHUNG,HA NA KIM,JONGIL JU, YUN-HO SONG,HYUNG-MIN CHUNG,DONG RYUL LEE , SUNG-HWAN MOON, Functional equivalency in human somatic cell nuclear transfer – derived endothelial cells,STEM CELLS,2019
  • Hye-Ryeon He, Haengseok Song, Hye-Ryun Kim, Jeong Eun Lee, Young Gie Chung, Woo Jin Kim, Se-Ran Yang,Kye-Seong Kim, Taehoon Chun, Dong Ryul Lee , and Seok-Ho Hong, Reprogramming mechanisms influence the maturation of hematopoietic progenitors from human pluripotent stem cells,Cell Death & Disease,2018
  • Jae-Il Bang , Eun-Hye Lee, Ah Reum Lee, Jin Il Lee , Seo Hye Choi, Dong-Won Seol,Chang-Hwan Park & Dong Ryul Lee ,The effect of cell penetrating peptide-conjugated coactivator-associated arginine methyltransferase 1 (CPP-CARM1) on the cloned mouse embryonic development,scientific reports,2018
  • Lim JJ, Han CY, Lee DR, Tsang BK. Ring finger protein 6 mediates androgen-induced granulosa cell proliferation and follicle growth via modulation of androgen receptor signaling. Endocrinol in revision 2017 (Co-corresponding authors). Jeong HS, Bhin J, Kim HJ, Hwang DH, Lee DR, Kim KS. Transcriptional regulatory networks underlying reprogramming of spermatogonial stem cells to multipotent stem cells. Exp Mol Med 2017 in press.
  • Shim H, Seol DW, Nam M, Song H, Lee DR, Lim HJ. Expression of Egr3 in mouse gonads and its localization and function in oocytes. Asian-Australas J Anim Sci. 2016 Dec 17. doi: 10.5713/ajas.16.0798. [Epub ahead of print] (Co-corresponding authors).
  • Yang NJ, Seol DW, Jo J, Jang HM, Yoon SY, Lee WS, Lee DR. Supplementation with cell-penetrating peptide-conjugated estrogen-related receptor β (CPP-ESRRB) improves the formation of the inner cell mass and the development of vitrified/warmed mouse embryos. Reprod Sci 2016 Nov;23(11):1509-1517. (co-corresponding authors).
  • Jang H, Lee OH, Lee Y, Yoon H, Chang EM, Park M, Lee JW, Hong K, Kim JO, Kim NK, Ko JJ, Lee DR, Yoon TK, Lee WS, Choi Y. Melatonin prevents cisplatin-induced primordial follicle loss via suppression of PTEN/AKT/FOXO3a pathway activation in the mouse ovary. J Pineal Res. 2016 Feb 16.
  • Kim YS, Kim HR, Kim H, Yang SC, Park M, Yoon JA, Lim HJ, Hong SH, DeMayo FJ, Lydon JP, Choi Y, Lee DR, Song H. Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice. Sci Rep. 2016 Feb 2;6:20242.
  • Jo J, Hwang S, Kim HJ, Hong SM, Lee JE, Lee SG, Baek A, Han H, Lee I, Lee DR. An integrated systems biology approach identifies positive cofactor 4 as a pluripotency regulatory factor. Nucleic Acids Res. Feb 18;44(3):1203-15.2016 (Co-corresponding authors).
  • Chang EM, Lim E, Yoon S, Jeong K, Bae S, Lee DR, Yoon TK, Choi Y, Lee WS. Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice. PLoS One. Dec 14;10(12):e0144245. 2015
  • Chung YG, Matoba S, Liu Y, Eum JH, Lu F, Jiang W, Lee JE, Sepilian V, Cha KY, Lee DR, Zhang Y. Histone demethylase-assisted somatic cell nuclear transfer facilitates efficient derivation of human pluripotent stem cells. Cell Stem Cells 17(6):758-66, 2015 (Co-corresponding authors).
  • Jeong JH, Park M, Park M, Lim EJ, Kim HR, Song H, Park SG, Choi SJ, Hong KH, Lee DR, Ko NN, Choi Y. The expression of aminoacyl-tRNA-synthetase-interacting multifunctional protein-1 (Aimp1) is regulated by estrogen in the mouse uterus. Mol Cell Endocrinol. 2015 Jan 5;399:78-86.
  • Kim HR, Kim YS, Yoon JA, Lyu SW, Shin H, Lim HJ, Hong SH, Lee DR, Song H. Egr1 is rapidly and transiently induced by estrogen and bisphenol A via activation of nuclear estrogen receptor-dependent ERK1/2 pathway in the uterus. Reprod Toxicol. 2014 Dec;50:60-7. doi: 10.1016/j.reprotox.2014.10.010. Epub 2014 Oct 18.
  • Lim JJ, Seol DW, Choi KH, Shin DH, Kim HJ, Song SH, Lee DR. Spermatogonial stem cell enrichment using simple grafting of testis and in vitro cultivation. Sci Rep Aug 1; 4:5923, 2014 (corresponding authors).
  • Lee J, Lee DR, Lee S. The genetic variation in Monocarboxylic acid transporter 2 (MCT2) has functional and clinical relevance with male infertility. Asian J Androl. 2014 Sep-Oct;16(5):694-7.. doi: 10.4103/1008-682X.124561. [Epub ahead of print]
  • Chung Y, Eum JH, Lee JE, Shim SH, Sepilian V, Hong SW, Lee Y, Treff N, Choi YH, Kimbrel E, Dittman R, Lanza R, Lee DR. Human somatic cell nuclear transfer using adult cells. Cell Stem Cells 14(6):777-80, 2014 Apr 15. pii: S1934-5909(14)00137-4. doi: 10.1016/j.stem.2014.03.015. [Epub ahead of print] (co-corresponding authors).
  • Lim JJ, Shim MS, Lee JE, Lee DR. Three-step method for the efficient proliferation and differentiation of human embryonic stem cell (hESC)-derived male germ cells. PLoS One 9(4):e90454, 2014 (corresponding authors).
  • Cha SK, Shin DH, Kim BY, Yoon SY, Yoon TK, Lee WS, Chung HM, Lee DR. Effect of human endothelial progenitor cell (EPC)- or mouse VEGF-derived vessel formation on the survival of vitrified/warmed mouse ovarian grafts. Reprod Sci 21(7):859-68, 2014. (corresponding authors).
  • Lim JJ, Lee JI, Kim DH, Song SH, Kim HJ, Lee WS, Lee DR. DNA fragmentation of human sperm can be detected by ligation-mediated real-time PCR. Fertil Steril 100(6): 1564-71, 2013. (corresponding authors).
  • Song SH, Lim JJ, Bang JK, Cha SK, Lee DR, Kim YS, Ahn TY, Yoon TK. Evaluation of sperm deoxyribonucleic acid damage and effects on embryo development using a mouse cryptorchidism model. Urology 2013 Jul 25. doi:pii: S0090-4295(13)00626-2.
  • Choi WY, Jeon HG, Chung Y, Lim JJ, Shin DH, Kim JM, Ki BS, Song SH, Choi SJ, Park KH, Shim SH, Moon JS, Kang HM, Park SA, Chung HM, Ko JJ, Cha KY, Yoon TK, Kim H, Lee DR. Isolation and characterization of novel, highly proliferative human CD34/CD73-double-positive testis-derived stem cells for cell therapy. Stem Cell Dev. 22(15):2158-73, 2013 Aug 1. (corresponding authors).
  • Chang EM, Han JE, Seok HH, Lee DR, Yoon TK, Woo Sik Lee. Insulin resistance does not affect early embryo development but lowers implantation rate in in vitro maturation-in vitro fertilization-embryo transfer cycle. Clin Endocrinol (Oxf) 79(1):93-9, 2013
  • Bang JK, Lyu SW, Choi J, Lee DR, Yoon TK, Song SH. Does infertility treatment increase male reproductive tract disorder? Urology 81(3):644-8, 2013.
  • Lim JJ, Kim HJ, Kim KS, Hong JY, Lee DR. In vitro culture-induced pluripotency of human spermatogonial stem cells. Biomed Res Int. 2013;2013:143028. doi: 10.1155/2013/143028. Epub 2012 Dec 24. (corresponding authors).
  • Kim MK, Park EA, Kim HJ, Choi WY, Cho JH, Lee WS, Cha KY, Kim YS, Lee DR, Yoon TK. Does supplementation of in-vitro culture medium with melatonin improve IVF outcome in PCOS? Reprod Biomed Online 26(1): 22-29, 2013 (co-corresponding author).
  • Baek KH, Lee HJ, Yang S, Lim SB, Lee W, Lee JE, Lim JJ, Jun K, Lee DR, Chung Y. Embryonic demise caused by targeted disruption of a cysteine protease Dub-2. PLOS One 7(9):e44223, 2012.
  • Choi J, Song SH, Bak CW, Sung SR, Yoon TK, Lee DR, Shim SH. Impaired spermatogenesis and gr/gr deletions related to Y chromosome haplogroups in Korean Men. PLOS One 7(8):e43550, 2012.
  • Yoon SY, Eum JH, Lee JE, Lee HC, Kim YS, Han JE, Won HJ, Park SH, Shim SH, Lee WS, Fissore RA, Lee DR, Yoon TK. Recombinant human phospholipase C zeta 1 induces intracellular calcium oscillations and oocyte activation in mouse and human oocytes. Hum Reprod 27(6):1768-80, 2012 (co-corresponding author).
  • Im JE, Song SH, Kim JY, Kim KL, Baek SH, Lee DR, Suh W. Vascular Differentiation of Multipotent Spermatogonial Stem Cells Derived from Neonatal Mouse Testis. Exp Mol Med. 44(4):303-309, 2012.
  • Park HT, Lee ES, Cheon YP, Lee DR, Yang KS, Kim YT, Hur JY, Kim SH, Lee KW, Kim T. The relationship between fat depot-specific preadipocyte differentiation and metabolic syndrome in obese women. Clin Endocrinol (Oxf) 76(1):59-66, 2012.

저서/역서/편서

    [특허]
  • Lee DR, Kaproth MT, Parks JE, IN VITRO PRODUCTION OF HAPLOID GERM CELLS, USA, US 6,872,569 B2, 2005.03.29.
  • Yoon TK, Lee DR, Chung HM, Cha KY, Chabiotech, Pochon CHA University. METHODS FOR VITRIFICATION OF HUMAN OOCYTES. USA, US7,947,497B2, 2011.05.24.
  • Lee DR, Choi WY, Yoon TK, SungKwang Medical Foundation. Testes somatic cell-derived pluripotent stem cells, method for producing same, and pharmaceutical composition for impotence treatment including same. PCT/WO2012/173358 A2.