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Haengseok Song

Haengseok Song Department Head

전공Molecular Reproductive Physiology
연락처 031-881-7150 hssong@cha.ac.kr

학력

  • 한양대학교 (생물학과), B.S.
  • 한양대학교 (생물학과), M.S.
  • 미국 University of Kansas Medical Center (분자생리학과), Ph.D.

경력

  • Washington University School of Medicine in St. Louis, 박사후연구원
  • 차의과학대학교 의생명과학과, 조교수
  • (현) 차의과학대학교 의생명과학과, 부교수
  • (현) Editorial Board of Biomolecules (MDPI)
  • (현) Board member of reviewing editors for Biology of Reproduction (USA)
  • (현) 대한생식의학회 국제교류협력위원장, 학술위원, 편집위원
  • (현) 대한생식면역학회 학술위원

논문

    [주요연구내용]
  • Uterine receptivity for embryo implantation using conditional knockout (cKO) mice with multiple Cre system
  • Therapeutic modulation of macrophage polarization to ameliorate various uterine disorders such as Asherman’s syndrome and preterm labor
  • Gene editing with CRISPR/Cas9 and AAV system using electroporation in mouse embryos
  • Development of gene and drug-delivery system to germs cells, preimplantation embryos and macrophages


    • [논문]
    국내
  • Song H (2006). Lessons from mouse models to understand uterine receptivity for embryo implantation. Korean J Fertil Steril 33(3):139-148 (교신저자)
  • Han SC, Song H, Jun JH (2008) Establishment and characterization of multi-potent germ line stem cells (MGSCs) from neonatal mouse testis. Korean J Reprod Med 35(1):39-48
  • Eo J, Song H, Lim HJ (2012) Etv5, a transcription factor with versatile functions in male reproduction Clin Exp Reprod Med 39(2):41-45
  • Seo BJ, Son JW, Kim HR, Hong SH, Song H (2014) Identification of Egr1 direct target genes in the uterus by in silico analyses with expression profiles from mRNA microarray data. Development and Reproduction 18(1):1-11

    • 국외
  • Park M, Hong SH, Park SH, Kim YS, Cho HY, Lee HK, Lim HJ, Lyu SW, Song H (2020) Perivascular stem cell-derived cyclophilin A improves uterine environment with Asherman’s syndrome via HIF1-dependent angiogenesis. Mol Ther (In press) (corresponding author)
  • Bora Lee B, Shin H, Oh JE, Park J, Park M, Yang SC, Jun JH, Hong SH, Song H, Lim HJ (2020) An autophagic deficit in the uterine vessel microenvironment provokes hyperpermeability through deregulated VEGF, nNOS, and β-catenin. Autophagy (In press) (corresponding author)
  • Song H, Park KH (2020) Regulation and function of SOX9 during cartilage development and regeneration. Semin Cancer Biol (In press)
  • Yoon SY, Yoon JA, Park M, Shin EY, Jung S, Lee JE, Eum JH, Song H, Lee DR, Lee WS, Lyu SW (2020) Recovery of ovarian function by human embryonic stem cell-derived mesenchymal stem cells in cisplatin-induced premature ovarian failure in mice. Stem Cell Res Ther (In press)
  • Lee MW, Yoon JA, Kim HR, Kim EK, Shin JE, Kim JH, Kwon H, Song H, Choi DH* (2020) Hyperandrogenic milieu dysregulates expression of factors in insulin signaling and glucose transporters in the endometrium of patients with polycystic ovary syndrome (PCOS). Reprod Sci (In press) (corresponding author)
  • Um DE, Shin H, Park D, Ahn JM, Kim J, Song H, Lim HJ (2020) Molecular analysis of lipid uptake- and necroptosis-associated factor expression in vitrified-warmed mouse oocytes. Reprod Biol Endocrinol 18:37 (corresponding author)
  • Kim JH, Park M, Paek JY, Lee WS, Song H, Lyu SW (2020) Intrauterine infusion of human platelet-rich plasma improves endometrial regeneration and pregnancy outcomes in a murine model of Asherman syndrome. Front Physiol 11:105 (corresponding author)
  • Kim YS, Kim GR, Park M, Yang SC, Park SH, Won JE, Lee JH, Shin HE, Song H, Kim HR (2020) Electroporation of AsCpf1/RNP at the zygote stage is an efficient genome editing method to generate knock-out mice deficient in leukemia inhibitory factor. Tissue Eng Regen Med 17(1):45-53 (corresponding author)
  • Kim KS, Han JH, Park JH, Kim HK, Choi SH; Kim GR, Song H, An HJ, Park W, Park KS, Han DK (2019) Multifunctional Nanoparticles for Genetic Engineering and Bioimaging of Natural Killer (NK) Cell Therapeutics. Biomaterials 221:119418
  • Ko DS, Lee DR, Song H, Kim JH, Lim CK (2019) Octylphenol and nonylphenol affect decidualization of human endometrial stromal cells. Reprod Toxicol 89:13-20
  • Lee JY, Song H, Dash O, Park M, Shin NE, McLane MW, Lei J, Hwang JY, Burd I (2019) Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model. Am J Reprod Immunol 82(3):e13151 (corresponding author)
  • Jun SM, Park M, Lee JY, Jung S, Lee JE, Shim SH, Song H, Lee DR (2019) Single cell-derived clonally expanded mesenchymal progenitor cells from somatic cell nuclear transfer-derived pluripotent stem cells ameliorate the endometrial function in the uterus of a murine model with Asherman’s syndrome. Cell proliferation 52(3):e12597 (corresponding author)
  • Kim YS, Park JS, Park M, Ko MY, Yi SW, Yoon JA, Yang SC, Shim SH, Park KH, Song H (2018) PLGA nanoparticles with multiple modes are a biologically safe nanocarrier for mammalian development and their offspring. Biomaterials 183:43-53 (corresponding author)
  • Lee MJ, Lee HA, Park M, Park HK, Kim YS, Yang SC, Kim HR, Kim J, Song H (2018) Estrogen-induced expression of decay accelerating factor is spatiotemporally antagonized by P4-progesterone receptor signaling in mouse uterus. Reprod Fertil Dev 30(11):1532-1540 (corresponding author)
  • Heo HR*, Song H*, Kim HR, Lee JE, Chung YG, Kim WJ, Yang SR, Kim KS, Chun T, Lee DR, Hong SH (2018) Reprogramming mechanisms influence the maturation of hematopoietic progenitors from human pluripotent stem cells. Cell Death & Disease 9:1090 *These authors equally contribute to this work
  • Park M, Kim HR, Kim YS, Yang SC, Lim HJ, Hong SH, Song H (2018) Estrogen-induced transcription factor EGR1 regulates c-Kit transcription in mouse uterus to maintain uterine receptivity for embryo implantation. Mol Cell Endocrinol 470:75-83 (corresponding author)
  • Kim HR, Kim YS, Yoon JA, Yang SC, Park M, Seol DW, Jun JH, Lee DR, Lim HJ, Song H (2018) Estrogen induces EGR1 to modulate its actions on uterine epithelial cells by controlling PR signaling for successful embryo implantation. FASEB J 32(3):1184-1195 (corresponding author)
  • Kim J*, Song H*, Heo HR*, Kim JW, Kim HR, Hong Y, Yang SR, Han SS, Lee SJ, Kim WJ, Hong SH (2017) Cadmium-induced ER stress and inflammation are mediated through C/EBP-DDIT3 signaling in human bronchial epithelial cells. Experimental & Molecular Medicine 49:e372 *These authors equally contribute to this work
  • An B, Kim E, Song H, Ha KS, Han ET, Park WS, An TG, Yang SR, Na S, Hong SH (2017) Gestational diabetes affects the growth and functions of perivascular stem cells. Mol Cells 40(6):434-439
  • Shin H, Seol DW, Nam M, Song H, Lee DR, Lim HJ (2017) Expression of Egr3 in mouse gonads and its localization and function in oocytes. Asian-Australas J Anim Sci 30(6):781-787
  • Kim HR, Cho KS, Kim E, Lee OH, Yoon H, Lee S, Moon S, Park M, Hong K, Na Y, Shin JE, Kwon H, Song H, Choi DH, Choi Y (2017) Rapid expression of RASD1 is regulated by estrogen receptor-dependent intracellular signaling pathway in the mouse uterus. Mol Cell Endocrinol 446:32-39
  • Shin H, Bang S, Kim J, Jun JH, Song H, Lim HJ (2017) The formation of multivesicular bodies in activated blastocysts is influenced by autophagy and FGF signaling in mice. Sci Rep 7:41986
  • Park J, Shin H, Song H, Lim HJ (2016) Autophagic regulation in steroid hormone-responsive systems. Steroids 115:177-181 (corresponding author)
  • Kim HR, Lee JH, Heo HR, Yang SR, Ha KS, Park WS, Han ET, Song H, Hong SH* (2016) Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway. Cell & Bioscience 6(1):50 (corresponding author)
  • Choi Y, Kim HR, Lim EJ, Park M, Yoon JA, Kim YS, Kim EK, Shin JE, Kim JH, Kwon H, Song H, Choi DH (2016) Integrative analyses of uterine transcriptome and microRNAome reveal compromised LIF-STAT3 signaling and progesterone response in the endometrium of patients with recurrent/repeated implantation failure (RIF). PLoS ONE 11(6): e0157696 (corresponding author)
  • Bae S, Kwon H, Yoon H, Park M, Kim HR, Song H, Hong K, Choi Y (2016). Estrogen-dependent expression of sine oculis homeobox 1 in the mouse uterus during the estrous cycle. Biochem Biophys Res Commun 472(3):489-495
  • Kim YS, Kim HR, Kim H, Yang SC, Park M, Yoon JA, Lim HJ, Hong SH, DeMayo FJ, Lydon JP, Choi Y, Lee DR, Song H (2016) Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice. Sci Rep 6:20242 (corresponding author)
  • An B, Na S, Lee S, Kim WJ, Yang SR, Woo HM, Kook S, Hong Y, Song H, Hong SH (2015) Non-enzymatic isolation followed by supplementation of basic fibroblast growth factor improves proliferation, clonogenic capacity and SSEA-4 expression of perivascular cells from human umbilical cord. Cell Tissue Res 359(3):767-777
  • Jeong JH, Park M, Park M, Lim EJ, Kim HR, Song H, Park SG, Choi SJ, Hong KH, Lee DR, Ko JJ, Choi Y (2015) The expression of aminoacyl-tRNA-synthetase-interacting multifunctional protein-1 (Aimp1) is regulated by estrogen in the mouse uterus. Mol Cell Endocrinol 399:78-86
  • Kim HR, Kim YS, Yoon JA, Lyu SW, Shin H, Lim HJ, Hong SH, Lee DR, Song H (2014) Egr1 is rapidly and transiently induced by estrogen and bisphenol A via activation of nuclear estrogen receptor-dependent ERK1/2 pathway in the uterus. Reprod Toxicol 50:60-67 (corresponding author)
  • Lim HJ, Song H (2014) Evolving tales of autophagy in early reproductive events. Int J Dev Biol 58:183-187 (corresponding author)

저서/역서/편서