차의과학대학교
 
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송행석

송행석 교수

전공생식생리학, 분자발생학
연락처 031-881-7150 hssong@cha.ac.kr

학력

  • 한양대학교 (생물학과), B.S.
  • 한양대학교 (생물학과), M.S.
  • 미국 University of Kansas Medical Center (분자생리학과), Ph.D.

경력

  • Washington University School of Medicine in St. Louis, 박사후연구원
  • 차의과학대학교 조교수, 부교수
  • (현) 차의과학대학교 의생명과학과/대학원 바이오융합과학과, 교수
  • (현) 대한생식면역학회 부회장
  • (현) Associate editor of CERM
  • (현) Editorial Board of Biomolecules (MDPI)
  • (현) Board member of reviewing editors for Biology of Reproduction (USA)
  • (현) Editorial Board of “Frontiers in Reproductive Health” as a review editor (Frontiers)

논문

    [연구실홈페이지]
  • http://mdg.cha.ac.kr/index.php


    • [주요연구내용]
  • 대식세포 극성조절 기반 염증성질환 및 암 치료 기전 연구
  • 생체 내 대식세포 극성조절 물질 전달체 활용기술 개발
  • 성체줄기세포 및 유래물질 기반 염증성 질환 치료 기전 연구
  • CRISPR/Cas9-AAV 시스템을 활용한 배아 유전체 편집 및 형질전환 동물모델 생산

    • [논문] (최근 5년간 교신저자 논문)
  • 1. Yang SC, Park M, Hong KH, La H, Park C, Wang P, Li G, Chen Q, Choi Y, DeMayo FJ, Lydon JP, Skalnik DG, Lim HJ, Hong SH, Park SH, Kim YS, Kim HR, Song H (2023) CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis. Nat Commun 14(1):3220
  • 2. Park M, Oh HJ, Han J, Hong SH, Park W, Song H (2022) Liposome-mediated small RNA delivery to convert the macrophage polarity: A novel therapeutic approach to treat inflammatory uterine disease. Mol Ther - Nucleic Acids 30:663-676
  • 3. Kim MK, Yoon JA, Yoon SY, Park M, Lee WS, Lyu SW, Song H (2022) Human platelet-rich plasma facilitates angiogenesis to restore impaired uterine environments with Asherman’s syndrome for embryo implantation and following pregnancy in mice. Cells 11(9):1549
  • 4. Yang SC, Yu EJ, Park JK, Kim TH, Eum JH, Paek SK, Hwang JY, Lyu SW, Kim JY, Lee WS, Yoon TK, Song H, Lee HJ (2021) The ratio of mitochondrial DNA to genomic DNA copy number in cumulus cells may serve as a biomarker of embryo quality in IVF cycles. Reprod Sci 28(9):2495-2502
  • 5. Park M, Park SH, Park H, Lim HJ, Song H (2021) ADAMTS-1 is a novel target of estrogen-induced transcription factor EGR1 critical for embryo implantation in the mouse uterus. Cell & Bioscience 11:155
  • 6. Lee B, Shin H, Oh JE, Park J, Park M, Yang SC, Jun JH, Hong SH, Song H, Lim HJ (2021) An autophagic deficit in the uterine vessel microenvironment provokes hyperpermeability through deregulated VEGF, nNOS, and β-catenin. Autophagy 17(7):1649-1666
  • 7. Park JK, Lee JH, Park EA, Lim HJ, Lyu SW, Lee WS, Kim J, Song H (2021) Development of optimized vitrification procedures for closed carrier system to improve survival and developmental competence of vitrified mouse oocytes. Cells 10(7):1670
  • 8. Lee JH, Park JK, Yoon SY, Park EA, Lim HJ, Kim J, Song H (2021) Advanced maternal age deteriorates the developmental competence of vitrified oocytes in mice. Cells 10(6):1563
  • 9. Kim YS, Yang SC, Park M, Y Choi, DeMayo FJ, Lydon JP, Kim HR, Lim HJ, Song H (2021) Different Cre systems induce differential microRNA landscapes and abnormalities in the female reproductive tracts of Dgcr8 conditional knockout mice. Cell Proliferation 54(3):e12996
  • 10. Park HK, Park SH, Lee M, Kim GR, Park M, Yang SC, Kim YS, Lim HJ, Kim HR, Song H (2020) Secretory phospholipase A2‑X (Pla2g10) is a novel progesterone receptor target gene exclusively induced in uterine luminal epithelium for uterine receptivity in mice. Cell & Bioscience 10:132
  • 11. Park M, Hong SH, Park SH, Kim YS, Yang SC, Kim HR, Noh S, Na S, Lee HK, Lim HJ, Lyu SW, Song H (2020) Perivascular stem cell-derived cyclophilin A improves uterine environment with Asherman’s syndrome via HIF1α-dependent angiogenesis. Mol Ther 28(8):1818-1832
  • 12. Lee MW, Yoon JA, Kim HR, Kim EK, Shin JE, Kim JH, Kwon H, Song H, Choi DH (2020) Hyperandrogenic milieu dysregulates expression of factors in insulin signaling and glucose transporters in the endometrium of patients with polycystic ovary syndrome (PCOS). Reprod Sci 27(8):1637-1647
  • 13. Um DE, Shin H, Park D, Ahn JM, Kim J, Song H, Lim HJ (2020) Molecular analysis of lipid uptake- and necroptosis-associated factor expression in vitrified-warmed mouse oocytes. Reprod Biol Endocrinol 18:37
  • 14. Kim JH, Park M, Paek JY, Lee WS, Song H, Lyu SW (2020) Intrauterine infusion of human platelet-rich plasma improves endometrial regeneration and pregnancy outcomes in a murine model of Asherman syndrome. Front Physiol 11:105
  • 15. Kim YS, Kim GR, Park M, Yang SC, Park SH, Won JE, Lee JH, Shin HE, Song H, Kim HR (2020) Electroporation of AsCpf1/RNP at the zygote stage is an efficient genome editing method to generate knock-out mice deficient in leukemia inhibitory factor. Tissue Eng Regen Med 17(1):45-53
  • 16. Lee JY, Song H, Dash O, Park M, Shin NE, McLane MW, Lei J, Hwang JY, Burd I (2019) Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model. Am J Reprod Immunol 82(3):e13151
  • 17. Jun SM, Park M, Lee JY, Jung S, Lee JE, Shim SH, Song H, Lee DR (2019) Single cell-derived clonally expanded mesenchymal progenitor cells from somatic cell nuclear transfer-derived pluripotent stem cells ameliorate the endometrial function in the uterus of a murine model with Asherman’s syndrome. Cell proliferation 52(3):e12597
  • 18. Kim YS, Park JS, Park M, Ko MY, Yi SW, Yoon JA, Yang SC, Shim SH, Park KH, Song H (2018) PLGA nanoparticles with multiple modes are a biologically safe nanocarrier for mammalian development and their offspring. Biomaterials 183:43-53
  • 19. Lee MJ, Lee HA, Park M, Park HK, Kim YS, Yang SC, Kim HR, Kim J, Song H (2018) Oestrogen-induced expression of decay accelerating factor is spatiotemporally antagonised by progesterone-progesterone receptor signalling in mouse uterus. Reprod Fertil Dev 30(11):1532-1540
  • 20. Park M, Kim HR, Kim YS, Yang SC, Lim HJ, Hong SH, Song H (2018) Estrogen-induced transcription factor EGR1 regulates c-Kit transcription in mouse uterus to maintain uterine receptivity for embryo implantation. Mol Cell Endocrinol 470:75-83 (Corresponding author)
  • 21. Kim HR, Kim YS, Yoon JA, Yang SC, Park M, Seol DW, Jun JH, Lee DR, Lim HJ, Song H (2018) Estrogen induces EGR1 to modulate its actions on uterine epithelial cells by controlling PR signaling for successful embryo implantation. FASEB J 32(3):1184-1195

저서/역서/편서