차의과학대학교
 
Home > 심성한

심성한

심성한 교수

전공의학유전학, 인류유전학
연락처 031-881-7148 shshim@cha.ac.kr

학력

  • 한양대학교 자연과학대학 생물학과 이학사
  • 한양대학교 의과대학 의학유전학교실 의학석사
  • 한양대학교 의과대학 의학유전학교실 의학박사 (Ph.D.)

경력

  • 보스턴대학교 Center for Human Genetics 박사후 연구원
  • 한양대학교 의과대학 의학유전학교실 연구교수
  • (현) 차 의과학대학교 생명과학대학 의생명과학과, 교수 (유전학전공)
  • (현) 차 의과학대학교 강남차병원 유전학 연구실장
  • 대한의학유전학회지 편집위원
  • 대한의학유전학회 유전학검사실 실사위원
  • 대한의학유전학회 인증위원회 세포유전학분과 위원장


    • [자격증]
  • 미국 임상분자유전학 전문의 (Clinical Molecular Geneticist, American Board of Medical Genetics, American Board of Medical Specialties), Certificate # 2005154
  • 미국 임상세포유전학 전문의 (Clinical Cytogeneticist, American Board of Medical Genetics, American Board of Medical Specialties), Certificate # 2007

논문

    [주요연구내용]
  • 분자세포유전학적 방법(molecular cytogenetic techniques)을 이용하여 사람 염색체이상 의 특성 분석.
  • 유전질환을 가진 환자 및 가계에서 유전자의 염기서열 분석을 통한 유전자의 돌연변이와 질환과의 상관관계 분석 및 환자 가계에서 산전진단법 확립
  • 유전체내에 산재하고 있는 다형현상과 질환과의 연관성 분석


    • [논문]
    <2018<
  • Sung Han Shim, Jung Oh Kim, Young Joo Jeon, Hui Jeong Ah, Hyun Ah Lee, Eun Hee Ahn, Woo Sik Lee, Nam Keun Kim. Association between vascular endothelial growth factor promoter polymorphisms and the risk of recurrent implantation failure. Experimental and Therapeutic Medicine, 15(2):2109-2119, 2018 Feb. Epub 2017 Dec 15 [SCIE/IF1.261] doi: 10.3892/etm.2017.5641/PMID 29434813
  • Se Yeon Won, Hannah Kim, Woo Sik Lee, Ji Won Kim, Sung Han Shim*. Pre-implantation genetic diagnosis and pre-implantation genetic screening: two years experience at a single center. Obstetrics & Gynecology Science, 61(1):95-101, 2018 Jan. Epub 2018 Jan 5 doi: 10.5468/ogs.2018.61.1.95/PMID 29372155 (co-correspondence)
  • Seung Yong Lee, Seung Jun Kim, Sung-Hee Han, Joon Soo Park, Hyo Jung Choi, Jeong Jin Ahn, Moon-Ju Oh, Sung Han Shim, Dong Hyun Cha, Seung Yong Hwang. A new approach of digital PCR system for non-invasive prenatal screening of trisomy 21. Clinica Chimica Acta 476:75-80, 2018 Jan. Epub 2017 Nov 21 [SCI/IF 2.926] doi: 10.1016/j.cca.2017.11.015/ PMID: 29170101

    • [2017]
  • Kye Hee Cho, Sung Han Shim*, MinYoung Kim. A de novo3p13 deletion induced by a complex chromosomal rearrangement combined with a pericentric inversion of chromosome, inv(3)(p13q12), and a translocation between chromosome 3 and 8, t(3;8)(q13.1;q24.2), in a child with developmental delay. Genes & Genomics, 39(2):121-126, 2017 Feb. Epub 2016 Oct 24 [SCIE/IF 0.692 ] doi:10.1007/s13258-016-0470-y (co-correspondence)
  • Sung Han Shim, Gwangil Kim, Dong Ryul Lee, Jeoung Eun Lee, Hee Jung Kwon, Won Kyung Song. Survival of transplanted human embryonic stem cell-derived retinal pigment epithelial cells in a human recipient for 22 months JAMA Ophthalmology, 2016:5824, 2017 Feb 9. [SCIE/IF 4.34] doi:10.1001/jamaophthalmol.2016.5824/PMID:28196199
  • Dong Keon Yon, Ji Eun Park, Seung Jun Kim, Sung Han Shim*, Kyu Young Chae. A sibship with duplication of Xq28 inherited from the mother; genomic characterization and clinical outcomes. BMC Medical Genetics 18:30, 2017 Mar 17. [SCIE/IF 2.198 ] doi: 10.1186/s12881-017-0394-7/PMID:28302064 (co-correspondence)
  • Ji Won Kim, Sung Han Shim*, Woo Sik Lee. De novo balanced reciprocal translocation t(2;3)(q31;q27) in a fetus conceived using PGD in a t(2;14)(q35;q32.1) balanced reciprocal translocation carrier mother. Clinical Case Reports 5(6):841-844, 2017 Apr 18. doi: 10.1002/ccr3.932/PMID:28588822 (co-correspondence)
  • Se Ra Sung, Seung Hun Song, Kyung Min Kang, Ji Eun Park, Yeo Jung Nam, Yun-Jung Shin, Dong Hyun Cha, Ju Tae Seo, Tae Ki Yoon, Sung Han Shim*. Sequence variations of the EGR4 gene in Korean men with spermatogenesis impairment. BMC Medical Genetics 18:47, 2017 May 2. [SCIE/IF 2.198 ] doi: 10.1186/s12881-017-0408-5/PMID:28464846
  • Kye Hee Cho, Sung Han Shim*, Min Young Kim. Clinical, biochemical, and genetic aspects of Sjögren-Larsson Syndrome. Clinical Genetics Epub 2017 May 23 [SCI/IF 3.326] doi: 10.1111/cge.13058/PMID:28543186 (co-correspondence)
  • Sang Hee Park, Sung Han Shim, Yong Wook Jung, So Hyun Shim, Mi Uk Chin, Ji Eun Park, Sung Mi Bae, Sang Woo Lyu, Dong Hyun Cha. Prenatal diagnosis of the isodicentric chromosome 22 associated with cat eye syndrome by multiplex ligation-dependent probe amplification. Journal of Genetic Medicine 14(1):43-47, 2017 June 30. doi: 10.5734/JGM.2017.14.1.43
  • Ji Hyon Jang, Yong Wook, Jung, Sung Han Shim, Yun Jeong Shin, Kyung Jin Lee, Sung Shin Shim, Eun Hee Ahn, Dong Hyun Cha. Global gene expression changes of amniotic fluid cell free RNA according to fetal development. European Journal of Obstetrics & Gynecology and Reproductive Biology 216:104-110, 2017 Sep. Epub 2017 Jul 15 [SCI/IF 1.666] doi: 10.1016/j.ejogrb.2017.07.017/PMID:28750298
  • Seung Yong Lee, Seung Jun Kim, Sung-Hee Han, Joon Soo Park, Hyo Jung Choi, Jeong Jin Ahn, Moon-Ju Oh, Sung Han Shim, Dong Hyun Cha, Seung Yong Hwang. A new approach of digital PCR system for non-invasive prenatal screening of trisomy 21. Clinica Chimica Acta 476:75-80, 2017 Nov 21. Epub 2017 Nov 15 [SCI/IF 2.873] doi: 10.1016/j.cca.2017.11.015/PMID:29170101
  • Seung-Hun Song, Sang Hee Park, Eunah Shin, Jae Hung Jung, Sung Han Shim, Dong Suk Kim. Male infertility associated with a supernumerary marker chromosome. World Journal of Men’s Health 35:e8, 2017 Dec. Epub 2017 Sep 6 [SCIE/IF 0] doi: 10.5534/wjmh.17015/PMID:28879694
  • So Hyun Shim, Ji Youn Kim, Se Ra Sung, Ji Eun Park, Yun Jeong Shin, Sung Han Shim, Dong Hyun Cha. Prenatally diagnosed TTN mutation with repeated bilateral club foot by whole exome sequencing. BioChip Journal Epub 2017 Aug 25 [SCIE/IF 1.30 ] doi: 10.1007/s13206-017-1309-6

    • [2016]
  • Seung-Hun Song, Dong Suk Kang, Tae Ki Yoon, Jae Yup Hong, Sung Han Shim*. Sexual function and stress level of male partners of infertile couples during the fertile period. BJU International 117(1):173-176, 2016 Jan. Epub 2015 Jul 14 [SCI/IF 4.387] PMID 26074135
  • Ji Sun Park, Se Won Yi, Hye Jin Kim, Seong Min Kim, Sung Han Shim*, Keun-Hong Park. Sunflower-type nanogels carrying a quantum dot nanoprobe for both superior gene delivery efficacy and tracing of human mesenchymal stem cells. Biomaterials, 77:14-25, 2016 Jan. Epub 2015 Nov 2 [SCI/IF 8.557] PMID 26576046 (co-correspondence)
  • Seung-Hun Song, Dong Suk Kang, Sung Han Shim, Jung Jin Lim, Seung Choul Yang. Usage and perceptions of phosphodiesterase type 5 inhibitors among the male partners of infertile couples. Clinical and Experimental Reproductive Medicine, 43(1):26-30, 2016 Mar. Epub 2016 Mar 31 PMID 27104154
  • Kyung Min Kang, Se Ra Sung, Ji Eun Park, Yun Jeong Shin, Sang Hee Park, Mi Uk Chin, Sang Woo Lyu, Dong Hyun Cha, Sung Han Shim*. Carrier screening for (CGG)n repeats expansion of FMR1 gene in Korean women. Journal of Genetic Medicine, 13(1):14-19, 2016 Jun. Epub 2016 Jun 30
  • Yong Wook Jung, Sung Shin Shim, Ji Eun Park, Se Ra Sung, Sung Han Shim, Hea Ree Park, Dong Hyun Cha. Analysis of the cell-free amniotic fluid transcriptome expressed during the Euploid mid-trimester of pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology, 203:94-98, 2016 Aug. Epub 2016 May 27 [SCI/IF 1.662] PMID 27261819
  • Youngsok Choi, Jung Oh Kim, Sung Han Shim, Yubin Lee, Ji Hyang Kim, Young Joo Jeon, Jung Jae Ko, Woo Sik Lee, Nam Keun Kim. Genetic variation of methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) genes is associated with idiopathic recurrent implantation failure. PLoS One, 11(8):e0160884, 2016 Aug 25. [SCI/IF 3.057] PMID 27560137
  • Soomin Hong, Junghyun Jo, Hyung Joon Kim, Jeoung Eun Lee, Dong Hyuk Shin, Sung-Geum Lee, Ahmi Baek, Sung Han Shim*, Dong Ryul Lee. RuvB-like protein 2 (Ruvbl2) has a role in directing the neuroectodermal differentiation of mouse embryonic stem cells. Stem Cells and Development, 25(18):1376-1385, 2016 Sep 15. Epub 2016 July 28 [SCI/IF 3.777] PMID 27469992 (co-correspondence)
  • Sun-Young Kong, Kwang-Soo Kim, Jiewan Kim, Min Kyeong Kim, Ki Hong Lee, Je-Yong Lee, Nuri Oh, Ji-In Park, Ji-Hoon Park, Sun-Hee Heo, Sung Han Shim, Dong Ryul Lee, Keun Pil Kim, Kyung-Soon Park. The ELK3-GATA3 axis orchestrates invasion and metastasis of breast cancer cells in vitro and in vivo. Oncotarget, 7(40):65137-65146, 2016 Oct 4. Epub 2016 Aug 19 [SCIE/IF 5.008 ] doi: 10.18632/oncotarget.11427/PMID 27556500
  • Yong Wook Jung, Yun Jeong Shin, Sung Han Shim, Dong Hyun Cha. An overview of current knowledge about cell-free RNA in amniotic fluid. Journal of Genetic Medicine 13(2):65-71, 2017 Dec 31. doi: 10.5734/JGM.2016.13.2.65

    • [2015]
  • Ji Won Kim, Sang Woo Lyu, Se Ra Sung, Ji Eun Park, Dong Hyun Cha, Tae Ki Yoon, Jung Jae Ko, Sung Han Shim*. Molecular analysis of miscarriage products using multiplex ligation-dependent probe amplification (MLPA): alternative to conventional karyotype analysis. Archives of Gynecology and Obstetrics, 291(2):347-354, 2015 Feb. Epub 2014 Aug 13 [SCIE/IF 1.364] PMID 25115280
  • Bona Lee, Kwiyeom Yoon, Sunghoon Lee, Jin Muk Kang, Junil Kim, Sung Han Shim, Hak-Min Kim, Sanghoon Song, Kazuhito Naka, An Keun Kim, Han-Kwang Yang, Seong-Jin Kim. Homozygous deletions at 3p22, 5p14, 6q15, and 9p21 result in aberrant expression of tumor suppressor genes in gastric cancer. Genes Chromosomes and Cancer, 54(3):142-155, 2015 Mar. Epub 2014 Dec 17 [SCI/IF 4.041]PMID 25521327
  • Won Kyung Song, Kyung-Mi Park, Hyun-Ju Kim, Jae Ho Lee, Jinjung Choi, So Young Chong, Sung Han Shim, Lucian V. Del Priore, Robert Lanza. Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: preliminary results in Asian Patients. Stem Cell Reports, 4(5):860-872, 2015 May 12. Epub 2015 Apr 30 [SCIE/IF 5.365]PMID 25937371
  • Jae Sun Shim, Kyunghoon Min, Seung Hoon Lee, Ji Eun Park, Sang Hee Park, MinYoung Kim, Sung Han Shim*. MEF2C-related 5q14.3 microdeletion syndrome detected by array CGH: A case report. Annals of Rehabilitation Medicine, 39(3):482-487, 2015 Jun. Epub 2015 Jun 30 PMID 26161356
  • J.H. Kang, H.J. Park, Y.W. Jung, S.H. Shim, S.R. Sung, J.E. Park, D.H. Cha, E.H. Ahn. Comparative transcriptome analysis of cell-free fetal RNA from amniotic fluid and RNA from amniocytes in uncomplicated pregnancies. PLoS One, 10(7):e0132955, 2015 Jul 16. [SCIE/IF 3.234] PMID 26181329
  • Seung Yong Lee, Sung Han Shim*, Jong-Pil Youn, Seung Jun Kim, Ji Hoon Kim, Sung A Jung, Hyo Jung Choi, Moon Ju Oh, Kyoung-Ryul Lee, Dong Hyun Cha, Seung Yong Hwang. New Application Methods for Chromosomal Abnormalities Screening Test Using Digital PCR. BioChip Journal 9(4):339-352, 2015 Dec. Epub 2015 Dec 18 [SCIE/IF 1.09] (co-first)

    • [2014]
  • Mi Kyung Kim, Hyun Ha Seok, You Shin Kim, Mi Uk Chin, Se Ra Sung, Woo Sik Lee, Sung Han Shim*, Tae Ki Yoon. Molecular genetic and cytogenetic characterization of a partial Xp duplication and Xq deletion in a patient with premature ovarian failure. Gene, 534(1):54-59, 2014 Jan 15. Epub 2013 Oct 19 [SCI/IF 2.196] PMID 24148559 (co-correspondence)
  • Sung Han Shim, Jae Sun Shim, Kyunghoon Min, Hee Song Lee, Ji Eun Park, Sang Hee Park, Euna Hwang, MinYoung Kim. Siblings with opposite chromosome constitutions, dup(2q)/del(7q) and del(2q)/dup(7q). Gene, 534(1):100-106, 2014 Jan 15. Epub 2013 Oct 2 [SCI/IF 2.196] PMID 24095776
  • Young Gie Chung, Jin Hee Eum, Jung Eun Lee, Sung Han Shim, Vicken Sepilian, Seung Wook Hong, Yumie Lee, Nathan R Treff, Young Ho Choi, Erin A. Kimbrel, Ralph E. Dittman, Robert Lanza, Dong Ryul Lee. Human somatic cell nuclear transfer using adult cells. Cell Stem Cell, 14(6):777-780, 2014 June. Epub 2014 Apr 17 [SCI/IF 25.315] PMID 24746675
  • Sang Hee Park, Sung Han Shim, Yong Wook Jung, Da Hee Kim, Su Jin Kang, Sun Ok Park, Dong Hyun Cha. Characterization of a prenatally diagnosed de novo der(X)t(X;Y)(q27;q11.23) of fetus. Journal of Genetic Medicine, 11(1):16-21, 2014 June.
  • Ji Won Kim, Kyung Min Kang, Tae Ki Yoon, Sung Han Shim, Woo Sik Lee. Study of circulating hepcidin in association with iron excess, metabolic syndrome and BMP-6 expression in granulosa cells in the women with polycystic ovary syndrome. Fertility and Sterility, 102(2):548-554.e2, 2014 Aug. Epub.2014 May 27 [SCI/IF 4.295] PMID 24875397
  • Mi Kyoung Kim, Hyung Jae Won, Sung Han Shim, Dong Hyun Cha, Tae Ki Yoon. Spontaneous ovarian hyperstimulation syndrome following a thawed embryo transfer cycle. Clinical and Experimental Reproductive Medicine, 41(3):140-145, 2014 Sep. Epub 2014 Sep 30 PMID 25309860
  • Myung Joo Kim, Sang Woo Lyu, Hyun Ha Seok, Ji Eun Park, Sung Han Shim*, Tae Ki Yoon. A healthy delivery of twins by assisted reproduction followed by preimplantation genetic screening in a woman with X-linked dominant incontinentia pigmenti. Clinical and Experimental Reproductive Medicine, 41(4):168-173, 2014 Dec. Epub 2014 Dec 31 PMID 25599040 (co-correspondence)

    • [2013]
  • HyungChul Rah, Young Joo Jeon, Sung Han Shim, Sun Hee Cha, Dong Hee Choi, Hwang Kwon, Ji Hyang Kim, Ji Eun Shin, Nam Keun Kim. Association of miR-146aC>G, miR-196a2T>C, and miR-499A>G polymorphisms with risk of premature ovarian failure in Korean women. Reproductive Sciences, 20(1):60-68, 2013 Jan. Epub 2012 Aug 17 [SCI/IF 2.444] PMID:22872486
  • S. W. Lyu, H. Song, J. A. Yoon, Mi-Uk Chin, S. R. Sung, Y. S. Kim, W. S. Lee, T. K. Yoon, D. H. Cha, S. H. Shim*. Transcriptional profiling with a pathway-oriented analysis in the placental villi of unexplained miscarriage. Placenta, 34(2):133-140, 2013 Feb. Epub 2012 Dec 21 [SCI/IF3.693] PMID:23266290
  • Jae Sang Byun, Sang Woo Lyu, Hyun Ha Seok, Won Jun Kim, Sung Han Shim, Chong Won Bak. Sexual dysfunctions induced by stress of timed intercourse and medical treatment. BJU International, 111(4 Pt B):E227-E234, 2013 Apr. Epub 2012 Oct 26 [SCI/IF2.844] PMID:23107357
  • Bo Eun Lee, Young Joo Jeon, Ji Eun Shin, Ji Hyang Kim, Dong Hee Choi, Yong Wook Jung, Sung Han Shim, Woo Sik Lee, Nam Keun Kim. Tumor necrosis factor- gene polymorphisms in Korean patients with recurrent spontaneous abortion. Reproductive Sciences, 20(4): 408-413, 2013 Apr. Epub 2012 Nov 29 [SCI/IF 2.444] PMID:23202728
  • Jin-Su Kim, Daekee Kwon, Seung-Taeh, Dong Ryul Lee, Sung Han Shim, Hee-Chun Kim, Hansoo Park, Won Kim, Myung-Kwan Han, Soo-Hong Lee. hESC expansion and stemness are independent of connexin forty three-mediated intercellular communication between hESCs and hASC feeder cells. PLoS One, 8(7):e69175, 2013 Jul 26 [SCIE/IF 3.73] PMID:23922689
  • Won Yun Choi, Hwang Gyun Jeon, Young Chung, Jung Jin Lim, Dong Hyuk Shin, Jung Mo Kim, Byeong Seong Ki, Seung-Hun Song, Seong-Jun Choi, Keun-Hong Park, Sung Han Shim, Jisook Moon, Sung Jun Jung, Hyun Mi Kang, Seah Park, Hyung Min Chung, Jung Jae Ko, Kwang Yul Cha, Tae Ki Yoon, Haekwon Kim, Dong Ryul Lee. Isolation and characterization of novel, highly proliferative human CD34/CD73-double positive testis-derived stem cells for cell therapy. Stem Cells and Development, 22(15):2158-2173, 2013 Aug 1. Epub 2013 Mar 19 [SCI/IF 4.67] PMID:23509942
  • Mi-Ok Lee, Sung Hwan Moon, Ho-Chang Jeong, Ji-Yeon Yl, Tae-Hee Lee, Sung Han Shim, Yong-Hee Rhee, Sang-Hun Lee, Seok-Jeong Oh, Moo-Yeol Lee, Min-Joon Han, Yee Sook Cho, Hyung-Min Chung, Kwang-Soo Kim, Hyuk-Jin Cha. Inhibition of pluripotent stem cell-derived teratoma formation by small molecules. Proc Natl Acad Sci USA, 110(35):E3281-3290, 2013 Aug 27. Epub 2013 Aug 5 [SCI/IF 9.737] PMID:23918355
  • oung Joo Jeon, Ji Hyang Kim, Bo Eun Lee, HyungChul Rah, Ji Eun Shin, Hojeong Kang, Dong Hee Choi, Tae Ki Yoon, Woo Sik Lee, Sung Han Shim*, Nam Keun Kim. Association between polymorphisms in the renin-angiotensin system genes and prevalence of spontaneous aborted fetuses. American Journal of Reproductive Immunology, 70(3):238-245, 2013 Sep. Epub 2013 Mar 11 [SCI/IF 3.317]. (co-correspondence) PMID 23480300
  • HyungChul Rah, Young Joo Jeon, Bo Eun Lee, Jung O Kim, Sung Han Shim, Woo Sik Lee, Dong Hee Choi, Ji Hyang Kim, Nam Keun Kim. Association of polymorphisms in microRNA machinery genes (DROSHA, DICER1, RAN, and XPO5) with risk for idiopathic primary ovarian insufficiency in Korean women. Menopause, 20(10):1067-1073, 2013 Oct. Epub 2013 Apr 1 [SCI/IF 3.163] PMID 23549446
  • Soo Hyun Kim, Sung Han Shim, Se Ra Sung, Kyung A Lee, Jung Yun Shim, Dong Hyun Cha, Kyoung Jin Lee. Gene expression analysis of the microdissected trophoblast layer of human placenta after the spontaneous onset of labor. PLoS One, 8(10):e77648, 2013 Oct 17. [SCIE/IF 3.73] PMID:24147045
  • Seung-Hun Song, Hyung Jae Won, Tae Ki Yoon, Dong Hyun Cha, Jeong Yun Shim, Sung Han Shim*. A case of the rare variant of Klinefelter syndrome 47,XY,i(X)(q10). Clinical and Experimental Reproductive Medicine, 40(4):174-176, 2013 Dec. PMID:24505564

    • [2012]
  • Eun Mi Chang, Ji Eun Han, In Pyung Kwak, Woo Sik Lee, Tae Ki Yoon, Sung Han Shim*. Preimplantation genetic diagnosis for couples with a Robertsonian translocation: practical information for genetic counseling. Journal of Assisted Reproduction and Genetics, 29(1):67-75, 2012 Jan. Epub 2011 Nov 12 (IF 1.253) PMID:22081077
  • Young Joo Jeon, Yi Seul Choi, HyungChul Rah, Su Yeoun Kim, Dong Hee Choi, Sun Hee Cha, Ji Eun Shin, Sung Han Shim, Woo Sik Lee, Nam Keun Kim. Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women. Gene, 494(2):168-173, 2012 Feb 25. Epub 2011 Dec 28 (IF 2.266) PMID:22222140
  • Seoyeon Kim, Yea Woon Kim, Sung Han Shim, Chul Geun Kim, AeRi Kim. Chromatin structure of the LCR in the human –globin locus transcribing the adult – and –globin genes. The International Journal of Biochemistry and Cell Biology, 44(3):505-513, 2012 Mar. Epub 2011 Dec 13 (IF 4.956) PMID:22178075
  • Ji Won Kim, Min Ho Lee, Ji Eun Park, Tae Ki Yoon, Woo Sik Lee, Sung Han Shim*. Association of IL-18 genotype with impaired glucose regulation in Korean women with polycystic ovary syndrome. European Journal of Obstetrics & Gynecology and Reproductive Biology, 161(1):51-55, 2012 Mar. Epub 2012 Jan 5 (IF 1.764) PMID:22226490 (co-correspondence)
  • 김지원, 박정원, 박상희, 윤태기, 차동현, 심성한*. 남성불임환자에서 정상 Y염색체와 isodicentric Y 염색체의 모자이크현상: 증례보고 및 문헌고찰. Journal of Reproductive Endocrinology, 4(1):49-55, 2012 Apr.
  • Sang Hee Jung, Sung Han Shim*, Sang Hee Park, Ji Eun Park, Hea Ree Park, Eun Hee Ahn, Soo Hyun Kim, Dong Hyun Cha. Prenatal diagnosis of partial trisomy 3q resulting from t(3;4) in a fetus with multiple anomalies including vermin hypoplasia. Gene, 498(2):237-241, 2012 May 1. Epub 2012 Feb 16 (IF 2.266) PMID:22366303 (co-first author)
  • HyungChul Rah, Yi Seul Choi, Young Joo Jeon, Youngsok Choi, Sun Hee Cha, Dong Hee Choi, Jung Jae Ko, Sung Han Shim*, Nam Keun Kim. Solute Carrier Family 19, Member 1 (SLC19A1) Polymorphisms (-43T>C, 80G>A, and 696C>T), and Haplotypes in Idiopathic Recurrent Spontaneous Abortion in a Korean Population. Reproductive Sciences 19(5):513-519, 2012 May. Epub 2012 Feb 16. (IF 2.586) PMID:22344739 (co-correspondence)
  • Ji-Seon Lee, Hong Jun Lee, Bo-Hyun Moon, Seung-Hyun Song, Mi-Ok Lee, Sung Han Shim, Hyung Seok Kim, Cheol Lee, Jeong Taik Kwon, Albert J. Fornace, Seung U. Kim, Hyuk-Jin Cha. Generation of cancerous neural stem cells forming glial tumor by oncogenic stimulation. Stem Cell Reviews and Reports, 8(2):532-545, 2012 May. Epub 2011 Jul 14. (IF 3.766) PMID:21755312
  • Chongwon Bak, Jae Sang Byun, Jee Han Lee, Ji Hye Park, Kyung-Ah Lee, Sung Han Shim*. Clinical and social characteristics of Korean men with Klinefelter syndrome. International Journal of Urology, 19(5):443-449, 2012 May. Epub 2012 Feb 9. (IF 1.46) PMID:22320868
  • Sook-Young Yoon, Jin Hee Eum, Jeoung Eun Lee, Hoi Chang Lee, You Shin Kim, Ji Eun Han, Hyung Jae Won, Sang Hee Park, Sung Han Shim, Woo Sik Lee, Rafael A. Fissore, Dong Ryul Lee, Tae Ki Yoon. Recombinant human phospholipase C zeta 1 induces intracellular calcium oscillations and oocyte activation in mouse and human oocytes. Human Reproduction, 27(6):1768-1780, 2012 Jun. Epub 2012 Mar 28. (IF 4.357) PMID:22456923
  • Mee-Hwa Lee, Seok Won Park, Tae Ki Yoon, Sung Han Shim. Homozygous CYP17A1 mutation (H373L) identified in a 46,XX female with combined 17-hydeoxylase/17,20-lyase deficiency. Gynecological Endocrinology, 28(7):573-576, 2012 Jul. Epub 2012 Mar 28. [IF 1.461] PMID:22452398
  • Jin Choi, Seung-Hun Song, Chong Won Bak, Se Ra Sung, Tae Ki Yoon, Dong Ryul Lee, Sung Han Shim*. Impaired spermatogenesis and gr/gr deletions related to Y chromosome haplogroups in Korean men. PLoS One, 7(8):e43550, 2012 Aug 23. [IF 4.092]
  • Seung-Hun Song, Sung Han Shim*, Jeong Kyoon Bang, Ji Eun Park, Se Ra Sung, Dong Hyun Cha. Genome-wide screening of severe male factor infertile patients using BAC-array comparative genomic hybridization (CGH). Gene, 506(1):248-252, 2012 Sep 10. Epub 2012 June 28. [IF 2.341] PMID:22750321 (co-first author)
  • Iksoo Jeon, Nayeon Lee, Jia-Yi Li, In-Hyun Park, Kyung Sun Park, Jisook Moon, Sung Han Shim, Chunggab Choi, Da-Jeong Chang, Jihye Kwon, Seung-Hun Oh, Dong Ah Shin, Hyun Sook Kim, Jeong Tae Do, Dong Ryul Lee, Manho Kim, Kyung-Sun Kang, George Q Daley, Patrik Brundin, Jihwan Song. Neuronal properties, in vivo effects and pathology of a Huntington’s disease patient-derived induced pluripotent stem cells. Stem Cells. 30(9):2054-2062, 2012 Sep. Epub 2012 May 24. [IF 7.871] PMID:22628015
  • HyungChul Rah, Young Joo Jeon, Youngsok Choi, Sung Han Shim, Jung Je Ko, Tae Ki Yoon, Sun Hee Cha, Nam Keun Kim. Association between kinase insert domain-containing receptor (KDR) polymorphisms (-604T>C, 1192G>A, 1719A>T) and premature ovarian failure in Korean women. Menopause, 19(9):1037-1042, 2012 Sep. Epub 2012 Apr 16. [IF 3.758] PMID:22510937
  • Young Joo Jeon, Su Yeoun Kim, HyungChul Rah, Dong Hee Choi, Sun Hee Cha, Tae Ki Yoon, Woo Sik Lee, Sung Han Shim*, Nam Keun Kim. Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G polymorphisms with risk of spontaneously aborted fetuses. American Journal of Reproductive Immunology, 68(5):408-417, 2012 Nov. Epub 2012 Aug 13. [IF 3.05] PMID:22882355 (co-correspondence)
  • HyungChul Rah, Young Joo Jeon, Youngsok Choi, Sung Han Shim, Tae Ki Yoon, Dong Hee Choi, Sun Hee Cha, Nam Keun Kim. Association of methylenetetrahydrofolate reductase (MTHFR 677C>T) and thymidylate synthase (TSER and TS 1494del6) polymorphisms with premature ovarian failure in Korean women. Menopause, 19(11):1260-1266, 2012 Nov. Epub 2012 June 18. [IF 3.758] PMID:22713864
  • Chong Won Bak, Sang Woo Lyu, Hyun Ha Seok, Jae Sang Byun, Sung Han Shim, Tae Ki Yoon. Erectile dysfunction and extramaterial sex induced by timed intercourse: a prospective study of 439 men. Journal of Andrology, 33(6):1245-1253, 2012 Nov. Epub 2012 May 3.[IF 2.968] PMID:22556386

    • [2011]
  • Ji Won Kim, Eun Mi Chang, Seung Hun Song, Sang Hee Park, Tae Ki Yoon, Sung Han Shim*. Complex chromosomal rearrangements in infertile males: complexity of rearrangement affects spermatogenesis. Fertility and Sterility, 95(1):349-352.e5, 2011. (IF 3.970) PMID: 20864097
  • Kang JH, Song H, Yoon JA, Park DY, Kim SH, Lee KJ, Farina A, Cho YK, Kim YN, Park SW, Kim GJ, Shim SH, Cha DH. Preeclampsia leads to dysregulation of various signaling pathways in placenta. Journal of Hypertension, 29(5):928-936, 2011. (IF 4.988) PMID: 21430563
  • 김수현, 심성한, 백종우, 차동현. 융모막 융모생검 511례에 대한 임상적 연구: 10년 (2000-2010년)간의 경험. Journal of Genetic Medicine, 8(1):35-43, 2011.
  • Mi Jeong Kim, Kyung Seon Shin, Jin Hee Jeon, Dong Ryul Lee, Sung Han Shim, Jin Kyeoung Kim, Dong-Hyun Cha, Tae Ki Yoon, Gi Jin Kim. Human chorionic-plate-derived mesenchymal stem cells and Wharton’s jelly-derived mesenchymal stem cells: a comparative analysis of their potential as placenta-derived stem cells. Cell & Tissue Research, 346(1):53-64, 2011. (IF 2.804) PMID:21987220
  • Ji Sun Park, Myung-Sun Shim, Sung Han Shim, Han Na Yang, Su Yeon Jeon, Dae Gyun Woo, Dong Ryul Lee, Tae Ki Yoon, Keun-Hong Park. Chondrogenic potential of stem cells derived from amniotic fluid, adipose tissue, or bone marrow encapsulated in fibrin gels containing TGF-3. Biomaterials, 32:8139-8149, 2011. (IF7.882) PMID:21840589
  • Young Joo Jeon, Ji Hyang Kim, Hyung Chul Rah, Su Yeoun Kim, Tae Ki Yoon, Dong Hee Choi, Sun Hee Cha, Sung Han Shim*, Nam Keun Kim. Vascular endothelial growth factor gene polymorphism in spontaneously aborted fetuses. American Journal of Reproductive Immunology, 66:544-553, 2011. (IF 2.451) PMID:21902756 (co-correspondence)
  • Young Joo Jeon, Youngsok Choi, Sung Han Shim, Yi Seul Choi, Jung Jae Ko, Tae Ki Yoon, Sun Hee Cha, Nam Keun Kim. Vascular endothelial growth factor gene polymorphisms in Korean patients with premature ovarian failure. European Journal of Obstetrics & Gynecology and Reproductive Biology, 159:138-142, 2011. (IF 1.764) PMID:21831507
  • Ji-hye Jeong, Mikyung Choi, Hyung Jae Won, Seung Hoon Song, You Shin Kim, Sang Woo Lyu, Hyun Ha Seok, Miree Park, Nam Keun Kim, Tae Ki Yoon, Sung Han Shim, Youngseok Choi. Novel single-nucleotide polymorphisms of SOHLH2 in Korean patients with premature ovarian failure. 발생과 생식, 15(4):309-313, 2011.

    • [2010]
  • ae-Hee Lee, Sun-Hwa Song, Koung Li Kim, Ji-Yeun Yi, Ga-Hee Shin, Ji Yeon Kim, Jihoon Kim, Yong-Mahn Han, Sang Hun Lee, Suk-Ho Lee, Sung Han Shim, and Wonhee Suh. Functional Recapitulation of Smooth Muscle Cells Via Induced Pluripotent Stem Cells From Human Aortic Smooth Muscle Cells. Circulation Research, 106:120-128, 2010. PMID: 19959777 (IF 9.989)
  • Dong Hee Choi, Se Ra Sung, Ji Eun Park, Dong Hyun Cha, Tae Ki Yoon, Sung Han Shim*. Mutation analysis of EXT1 and EXT2 genes in a Korean family with multiple exostoses. Genes & Genomics, 32:41-43, 2010. (IF 0.267)
  • Sook-Won Ryu, Goeun Lee, Cheong Soon Baik, Sung Han Shim, Jin-Tack Kim, Jung-Soo Lee, Kyung-A Lee. Down-Turner syndrome (45,X/47,XY,+21): Case report and review. Korean J Lab Med, 30:195-200, 2010. PMID: 20445340 (IF 0.626)
  • Sung Han Shim, Tae Ki Yoon, Dong Hyun Cha, Won Bo Han, Dong Hee Choi, Nam Keun Kim. Endothelial nitric oxide synthase (eNOS) gene polymorphisms in spontaneously aborted embryos. Genes & Genomics, 32:283-288, 2010. (IF 0.267)
  • Ji Hyeon Park, Jung Hoon Woo, Sung Han Shim, Song-Ju Yang, Young Min Choi, Kap-Seok Yang and Dong Hyun Cha. Application of a target array Comparative Genomic Hybridization to prenatal diagnosis in South Korea. BMC Med Genet, 11:102, 2010. (IF 2.84)
  • Youngsok Choi, Sanghyun Jeon, Mikyung Choi, Min-Ho Lee, Miseon Park, Dong-Ryul Lee, Kyu-Yeon Jun, Youngjoo Kwon, Ok-Hee Lee, Seung-Hun Song, Ji-Young Kim, Kyung-Ah Lee, Tae-Ki Yoon, Aleksandar Rajkovic, Sung Han Shim*. Mutations in SOHLH1 gene association with non-obstructive azoospermia. Human mutation, 31(7):788-793, 2010. PMID: 20506135 (IF 6.887)
  • Ji Won Kim, Chong Won Bak, Mi Uk Chin, Dong Hyun Cha, Tae Ki Yoon, Sung Han Shim*. SRY-negative 46,XX infertile male with Leydig cell hyperplasia: clinical, cytogenetic, and molecular analysis and review of literature. Fertility and Sterility, 94(2):753e5-753e9, 2010. PMID: 20227075 (IF 3.97). 7-1. Ji Won Kim, Chong Won Bak, Sung Han Shim. Reply of the Authors. Fertility and Sterrility, 94(2):e40, 2010.
  • Kyoung Jin Lee, Sung Han Shim, Kyung Min Kang, Jin Hee Kang, Dong Yoon Park, Sung Han Kim, Antonio Farina, Soung Shin Shim, Dong Hyun Cha. Global gene expression changes induced in the human placenta during labor. Placenta, 31(8):698-704, 2010. PMID: 20554320 (IF 2.767) (co-first author)
  • Seung Ju Shin, Hyun Haing Lee, Sun Hee Cha, Ji Hyang Kim, Sung Han Shim, Dong Hee Choi, Nam Keun Kim. Endothelial nitric oxide synthase gene polymorphisms (-786T>C, 4a4b, 894G>T) and haplotypes in Korean patients with recurrent spontaneous abortion. Eur J Obstet Gynecol Reprod Biol, 152(1):64-67, 2010. PMID: 20728041 (IF 1.582)
  • Seung-Taeh Hwang, Sun-Woong Kang, Suk-Jun Lee, Tae-Hee Lee, Wonhee Suh, Sung Han Shim, Dong-Ryul Lee, Lakeshia J. Taite, Kwang-Soo Kim, Soo-Hong Lee. The expansion of human ES and iPS cells on porous membranes and proliferating human adipose-derived feeder cells. Biomaterials, 31:8012-8021, 2010. PMID: 20674000 (IF7.365)
  • Sanghyun Jeon, Hyung Jae Won, You Shin Kim, Sang Woo Lyu, Hyun Ha Seok, Nam Keun Kim, Woo Sik Lee, Sung Han Shim, Tae Ki Yoon, Youngsok Choi. Novel single-nucleotide polymorphisms of LHX8 gene in Korean women with premature ovarian insufficiency. Genes & Genomics, 32:403-406, 2010. (IF 0.148)
  • Ji Won Kim, Woo Sik Lee, Tae Ki Yoon, Hyun Ha Seok, Jung Hyun Cho, You Shin Kim, Sang Woo Lyu, Sung Han Shim*. Chromosomal abnormalities in spontaneous abortion after assisted reproductive treatment. BMC Medical Genetics, 11:153, 2010. (IF 2.84) PMID: 21044350
  • Jeoung Eun Lee, Myung Seo Kang, Myung Hee Park, Sung Han Shim, Tae Ki Yoon, Hyung Min Chung, Dong Ryul Lee. Evaluation of 28 human embryonic stem cell lines for use as unrelated donors in stem cell therapy: implications of HLA and ABO genotypes. Cell Transplantation, 19(11):1383-1395, 2010. (IF 5.126) PMID: 20587141
  • 이민호, 주진영, 조율희, 심성한*. 생쥐의 수정란 배아줄기세포와 체세포핵이식 배아줄기세포에서 각인유전자, H19, Igf2r, Snrpn의 메틸화 경향. 발생과 생식, 14(4):253-259, 2010.

    • [2009]
  • Ji-Seon Lee., Mi-Ok Lee, Bo-Hyun Moon, Sung Han Shim, Albert J. Fornace Jr, Hyuk-Jin Cha. Senescent Growth Arrest in Mesenchymal Stem Cells Is Bypassed by Wip1-Mediated Downregulation of Intrinsic Stress Signaling Pathways. Stem Cells, 27(8): 1963-1975, 2009. PMID: 19544416 (IF 7.741)

    • [2008]
  • Chun Kyu Lim, Jae Won Cho, Jin Young Kim, Inn Soo Kang, Sung Han Shim, Jin Hyon Jun. A healthy live birth after successful preimplantation genetic diagnosis for carriers of complex chromosome rearrangements. Fertility and Sterility, 90 (5): 1680-1684, 2008. PMID: 18076880 (IF 4.167)
  • 박상희, 심성한, 진미욱, 강수진, 배성미, 손수민, 차동현, 윤태기, 조정현. 원발성 무월경 여성에서 관찰된 pseudoisodicentric X 염색체. Journal of Genetic Medicine, 5:61-64, 2008.
  • K. Han, J.E Lee, S.J. Kwon, S.Y. Park, S.H. Shim, H. Kim, J.H. Moon, C.S. Suh, H.J. Lim. Human amnion-derived mesenchymal stem cells are a potential source for uterine stem cell therapy. Cell proliferation, 41:709-725, 2008. PMID: 18823496 (IF 2.423)
  • Charles E. Mays, Hae-Eun Kang, Younghwan Kim, Sung Han Shim, Ji-Eun Bang, Hee-Jong Woo, Youl-Hee Cho, Jae-Beom Kim, Chongsuk Ryou. CRBL cells: Establishment, characterization and susceptibility to prion infection. Brain Research, 1208:170-180, 2008. PMID: 18395703 (IF 2.494)

저서/역서/편서