Asgerally Turabally Fazleabas

인사말

Asgerally Turabally Fazleabas교수

전문분야 | 
Endometriosis and Infertility
Uterine Biology & Maternal Fetal Interactions

E – mail | gjkim@cha.ac.kr

학력

California State University, Fresno, CA BS
University of Illinois, Urbana-Champaign MS
University of Illinois, Urbana-Champaign PhD

주요경력

Academic Appointments

1983-1984 Research Associate, Department of Obstetrics and Gynecology, University
of Illinois at Chicago,
Chicago, Illinois
1985-1990 Assistant Professor, Departments of Obstetrics and Gynecology and
Physiology and Biophysics,
University of Illinois at Chicago, Chicago, Illinois.
1990-1995 Associate Professor, Departments of Obstetrics and Gynecology and
Physiology and Biophysics,
University of Illinois at Chicago, Chicago, Illinois
1995-2009 Professor, Departments of Obstetrics and Gynecology and Physiology
and Biophysics,
University of Illinois at Chicago, Chicago, Illinois.
2002-2009 Director, Center for Women’s Health & Reproduction, University of
Illinois.
2009-Present
Professor and Associate Chair, Department of Obstetrics, Gynecology and
Reproductive Biology,
Director, Center for Women’s Health Research, Co-Director, Reproductive
& Developmental Sciences Program, Michigan State University.

Advisory Committees

1989-1995 Member, Editorial Board, Biol Reprod; Board of Directors, Soc Study of
Reprod.
Member, Editorial Board, Endocrinology
1993-1997 Member, NIH Study Section: Human Embryology and Development and
Reproductive Biology
1999-2004 Member, Editorial Board, Biol Reprod; Board of Directors, Soc Study of
Reprod.
Member, Editorial Board, Endocrinology
2000-2004 Member, NIH Study Section: Human Embryology and Development and
Reproductive Biology
2001-2004 Director, Frontiers in Reproduction Course, Woods Hole, MA
2002-2004 Chair, NIH Reproductive Biology/Cellular, Molecular and Integrative
Reproduction Study Section
2002 – 2006 Member, Advisory Board for the California and Oregon National Primate
Centers
2004-Present
Ad-Hoc Reviewer, NIH Study Sections – Cellular, Molecular and Integrative
Reproduction,
Integrated Cellular Endocrinology and Reproduction, Pregnancy and
Neonatology
2005-2008 Board of Reviewing Editors, Biology of Reproduction
2007-2015 Editorial Board, Fertility & Sterility and J Medical Primatology
2008 – 2012 NIH – NCRR Special Emphasis Panel P51 Primate Center Grant Review
(Chair 2012)
2010-2015 Editorial Board, Endocrinology, Am J Physiol – Endo & Metab, J.
Endometriosis & Pelvic Surgery, Reproductive Sciences
2012 – 2015 Chair, Board of Scientific Counselors, Frontiers in Reproduction

Honors

2000-2003 Senior University Scholar, University of Illinois
2005 Beacon Award, Frontiers in Reproduction
2005-2006 UIC Fellow, Academic Leadership Program, Committee on Institutional
Cooperation
2008 -2009 President, Society for the Study of Reproduction
2009 Visiting Research Professor Awardee – University of Sydney, Australia
2010 Research Award – Society for the Study of Reproduction
2011 Elected Fellow – American Society for the Advancement of Science
2013 World Class University Professor, Seoul National University, Seoul, Korea

연구내용

Understanding the critical cellular events that define synchrony between the developing embryo and the maternal uterus in a species that is phylogenetically related to humans will be paramount in improving the success of assisted reproductive therapies. Ongoing studies in the Fazleabas’ laboratory are at the leading edge of this type of research endeavor. His laboratory was the first to conclusively demonstrate that signals from the primate embryo, like those of other species, induce cell specific changes in uterine gene expression. These changes are thought to play critical roles in establishing a synchrony between the maternal environment and the developing embryo that is a pre requisite for a successful pregnancy. These studies have clearly elucidated the mechanisms by which apoptosis is inhibited within the uterus in the presence of a conceptus, the fundamental hormonal and cellular requirements associated with the process of decidualization and potential functions of uterine proteins in the establishment of pregnancy. The current focus of the work is on the mechanisms by which Notch signaling mediates uterine function during the establishment of pregnancy. A hallmark of all the studies from his laboratory is the ability to confirm all their in vitro findings in vivo as a fundamental application of true physiology in the appropriate tissue context. In addition, his laboratory has established a baboon model for endometriosis. The focus of these studies are to understand the etiology and pathophysiology of Endometriosis, a poorly understood, enigmatic disease that affects five to fifteen percent of all women of reproductive age and has an estimated economic impact of approximately 22 billion dollars in the US. It is reported to be the leading cause of infertility in women. The unique nature of the primate model that he has developed to study endometriosis and the strong multidisciplinary group that he has established has led to important and fundamental findings regarding the causative effects of endometriosis on aberrant gene expression in the eutopic endometrium that may contribute to infertility. Currently the focus is on the role of miRNA’s in regulating cell proliferation and apoptosis and the molecular mechanisms that contribute to progesterone resistance. In addition, the laboratory is also focusing on epigenetic modifications in both endometrial and endometriotic tissues and novel nanoparticle driven therapies to control the disease. Furthermore, studies from the. Fazleabas’ laboratory has also identified the genes that may be involved with the process of angiogenesis and cell adhesion during the establishment of lesions in the peritoneal environment.

[논문]

https://www.ncbi.nlm.nih.gov/pubmed/?term=Fazleabas